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Books of 2010: 48. Bad Science, by Ben Goldacre

Goldacre starts with the more easily-debunkable claims of alternative practitioners who leech out "toxins" using foot baths (hint: it involves electricity, salt water, and iron nails... and no "toxins"). From there, he moves on to the homeopath industry to show what's needed to produce good methodology in a paper, stuff like randomization, blinding, and proper controls. He tackles the nutrition and pharmacology industries, showing how you can misrepresent your results (ignore people who drop out, play with the baseline, play with the statistics, etc.) and how the media routinely dumb down or sensationalize certain stories while ignoring others. There's a fascinating chapter on the placebo effect (more complex than you might think) and a cautionary chapter on the MMR-vaccine / autism media debacle.
Through it all, Goldacre is quick to point out that he's not against sensible eating, or people taking (or not taking) pills, or medical interventions. His constant refrain in the book is, "It's a bit more complicated than that." What he is against is the alternative medicine industry and media's portrayal of science as something highly difficult to understand, something that exists in a black box. Goldacre asserts that sensible, intelligent, motivated people can understand science, and the media's dumbing down (and the alternative medicine industry's "science-y sounding" papers) aren't helping anyone, especially in an age when so many of our decisions ultimately come down to understanding science.
I think this is a wonderful introductory book for laypeople who may have (like me) forgotten most of their high school science.